Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma

DNA methylation of tumor suppressor genes in hepatocellular carcinoma

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

Topological Visualization Uncovers Novel Clinically Relevant Clusters

The objective of this project is to demonstrate how a topological exploration of three distinct clinical databases revealed or confirmed novel subgroups with associated features that may inform medical decision-making. Exploratory topological visualization using Iris is a valuable adjunct to traditional methods of statistical evaluation. Correlating identified clusters with clinical knowledge m...

Hepatocellular Carcinoma in Sheep

Proteomics of hepatocellular carcinoma in Chinese patients.

Hepatocellular carcinoma (HCC) is a malignant tumor of liver that causes approximately half a million deaths each year, of which over half of the cases are diagnosed in China. Because of its asymptomatic nature, HCC is usually diagnosed at late and advanced stages, for which there are no effective therapies. Thus, biomarkers for early detection and molecular targets for treating HCC are urgentl...

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...